Pakistan Journal of Medical Sciences

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Volume 23

October - December 2007 (Part-II)

Number 6


 

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Human Chorionic Gonadotropin (hCG):
A treatment of oligospermia

Mazhar Mushtaq1, Saghir Ahmed Jafri2, Abdus Salam Sheikh3,
Sadia Ahmad4, Farah Deeba5, Khurram Salam6

Abstract

The most commonly accepted definition of the term infertility is the lack of pregnancy (regardless of cause) after one year of unprotected intercourse. Infertility affects approximately 15% of couples of reproductive age. Its prevalence has been stable during the past 50 years, although a shift in etiology and in the age of the patient has occurred. In Pakistan there are roughly 10-15% newly married couples who require some kind of medical help before they can become parents. Even if the wife is fertile and the husband is normal, there is roughly 1 in 3 chances the wife will conceive. A total of 17 patients were diagnosed for Oligospermia and were placed in one group. 5000 IU of hCG were administered intramuscularly once a week for four month. Every month serum testosterone and semen count was analyzed. Progressive increase of semen count was observed in four month. hCG though, never produced in male but has significant effect on spermatogenesis via LH receptor. Initial value of 25 million/ml roused to 69 million/ml in just four month. Use of hCG in male infertility is though common world wide but it has not gained its popularity in Pakistan. General awareness of its usage especially among physicians treating infertility is required.

KEY WORDS: Infertility, Fertility, Oligospermia, hCG, LH, FSH, Testosterone, Semen count.

Abbreviations: Human Chorionic Gonadotropin (hCG); Luteinizing Hormone (LH); Follical Stimulating Hormone (FSH).

Pak J Med Sci    October - December 2007 (Part-II)    Vol. 23 No. 6    840-846


1. Dr. Mazhar Mushtaq,
2. Prof. Saghir Ahmed Jafri,
Director,
Institute of Molecular Biology and Biotechnology,
3. Prof. Abdus Salam Sheikh,
Head of Biochemistry Department,
University College of Medicine,
4. Dr. Sadia Ahmad,
5. Dr. Farah Deeba,
6. Dr. Khurram Salam
1,4-6: Senior Lecturer,
Biochemistry Department,
University College of Medicine,
1-6: The University of Lahore
Lahore – Pakistan.

Correspondence

Dr. Mazhar Mushtaq,
E-mail: dr_hcg@yahoo.com

* Received for Publication: July 9, 2007
* Revision Received: October 2, 2007
* Revision Accepted: October 3, 2007



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