Pakistan Journal of Medical Sciences

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Volume 24

October - December 2008 (Part-II)

Number 6


 

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The protective effect of Cetirizine against
Bleomycine induced pulmonary fibrosis in rats

Ali Asghar Hemmati1, Peyman Mikaili2, Mohammad Javad Khodayar3,
Mehri Ghafurian4, Iran Rashidi5

ABSTRACT

Objective: To evaluate the protective effect of cetrizine against bleomycin induced pulmonary fibrosis in rats.

Methodology: Male Sprague-Dawley rats (n=30), received an intratracheal injection of bleomycin (7.5 IU/kg) in saline solution for induction of pulmonary fibrosis. Two treatment groups received daily cetirizine five and 20mg/kg/day, seven days before and four weeks after administering a single-dose bleomycin (7.5IU/kg). The cytokines (IL-8, TNF-á, TGF-â1) through ELISA kits, the amount of collagen in the lungs (hydroxyproline content), and pharmacological activity of the lung strip tissues were determined.

Results: The cytokine levels have been decreased in the treated groups by cetirizine 5 (p< 0.05) and 20 (p<0.01) mg/kg/day, in comparison to positive control group.

Conclusions: Cetirizine may have a protective effect against bleomycine induced pulmonary fibrosis as evident by the reduction of the severity of lung tissue changes, collagen amounts and cytokines levels caused by bleomycine in rats lungs tissues.

KEYWORDS: Pulmonary fibrosis, Bleomycine, Cetirizine, Cytokines.

Pak J Med Sci    October - December 2008 (Part-II)    Vol. 24 No. 6    813-820

How to cite this article:

Hemmati AA, Mikaili P, Khodayar MJ, Ghafurian M, Rashidi I. The protective effect of Cetirizine against Bleomycine induced pulmonary fibrosis in rats. Pak J Med Sci 2008;24(6):813-20.


1. Ali Asghar Hemmati,
2. Peyman Mikaili,
3. Mohammad Javad Khodayar,
Dept. of Pharmacology & Toxicology, School of Pharmacy,
4. Mehri Ghafurian,
Department of Immonology,
5. Iran Rashidi,
Department of Pathology,
1-5: Jondishapour University of Medical Sciences,
Ahwaz, Iran.

Correspondence

Dr. Peyman Mikaili,
Pharmacy Faculty,
Ahwaz Jundishapour University of Medical Sciences,
Golestan Ave. P.O. Box: 6287, Ahvaz, Iran.
E-mail: payman_michaeli@yahoo.com

* Received for Publication: May 22, 2008
* Revision Received: August 18, 2008
* Second Revision Received: September 2, 2008
* Final Revision Accepted: September 3, 2008



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