Pakistan Journal of Medical Sciences


ISSN 1681-715X





Volume 25

 October - December 2009 (Part-II)

Number  6


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Trends of lipid abnormalities in Pakistani Type-2 Diabetes
Mellitus patients: A tertiary care centre data

Sehran Mehmood Bhatti1, Sajid Dhakam2, Mohammad Attaullah Khan3


Objective: To ascertain trends of lipid abnormalities in Pakistani Type-2 Diabetes Mellitus patients.

Methodology: Fasting lipid profiles of 328 outpatient adult type 2 diabetes mellitus patients visiting the Aga Khan University Hospital, from January 2005 to January 2006 were prospectively reviewed and abstracted on a pre-specified proforma. Demographic features, different patterns of dyslipidemia in accordance with specified risk categories, and the proportion of patients with none, one, two, or three lipid values outside clinical targets were noted. The influence of sex on dyslipidemia pattern was also assessed

Results: Our patients had higher average HbA1c levels and higher total cholesterol, LDL and lower HDL levels. The triglycerides levels in our female patients were higher. The percentage of our patients with a high-, borderline-, or low-risk LDL cholesterol were 54, 29, and 16%, respectively (P = 0.51). On a percentage basis, 73% were in the high-risk HDL cholesterol group, 18% were in the borderline-risk group and 9% in the low-risk group, respectively (P< 0.0001). Regarding triglyceride concentrations, 16% had high-risk triglyceride levels, 34% were in the borderline-risk category, whereas 50% had a low-risk triglyceride levels (P< 0.0001). Patient proportion with None, One, Two, or Three Values outside clinical targets on percentage basis were 2, 16, 48, and 34%, respectively (P< 0.0001). Women were found to have greater odds of having LDL cholesterol above the target level i.e. >100mg/dl.

Conclusion: Combination of high LDL and a low HDL cholesterol level was the commonest pattern of dyslipidemia found. Second was unfavorable levels of all three lipoproteins combined and the third was an isolated increase in LDL cholesterol. A greater proportion of women were found dyslipidemic.

KEY WORDS: Dyslipidemia patterns, High LDL, Type 2 DM dyslipidemia.

Pak J Med Sci    October - December 2009 (Part-II)    Vol. 25 No. 6    883-889

How to cite this article:

Bhatti SM, Dhakam S, Khan MA. Trends of lipid abnormalities in Pakistani Type-2 Diabetes Mellitus patients: A tertiary care centre data. Pak J Med Sci 2009;25(6):883-889.

1. Sehran Mehmood Bhatti, FCPS,
Consultant Cardiologist,
Aga Khan Hospital,
Daressalam, Tanzania.
2. Sajid Dhakam, MD, FACC, FSCAI
Associate Professor,
Section Head Cardiology,
Department of Medicine,
Aga Khan University Hospital, Karachi.
3. Mohammad Attaullah Khan, FRCP
Professor of Medicine
Department of Medicine,
Aga Khan University Hospital, Karachi.
Cardiology section,
Department of Internal Medicine,
The Aga Khan University Hospital,
Karachi - Pakistan.Correspondence:

Dr. Sehran Mehmood Bhatti
R106, Street #5,
Sector# 11-K, Islamic Bungalows,
North Karachi,
Karachi-75850 Pakistan.
* Received for Publication: July 28, 2009

* Revision Received: September 5, 2009

* Accepted Dated: September 7, 2009


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