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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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Volume 26 |
April - June 2010 |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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ISSN 1681-715X |
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ORIGINAL ARTICLE |
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Volume 26 |
April - June 2010 |
Number 2 |
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Comparison of Metformin and Cyproterone-estrodiol
Compound effect on hs C-reactive protein and serum
Androgen levels in patients with Poly Cystic Ovary SyndromeNasser Aghamohammadzadeh1, Akbar Aliasgarzadeh2, Leila Baglar3,
Seddigheh Abdollahifard4, Amir Bahrami5, Farzad Najafipour6, Mitra Niafar7ABSTRACT
Objectives: The aim of this study was comparison of the effects of Metformin and Cyproterone-estradiol compound on serum androgens & highly sensitive C-reactive protein levels.
Methodology: Sixty patients with Poly Cystic Ovary Syndrome (PCOS) were enrolled in this study conducted during a period of 16 months from December 2004 to March 2006. Thirty subjects were in each group and treated with Metformin one gram per day or Cyproterone-estradiol compound 21 days monthly and at the beginning and after 3 and 6 months, weight, height, testosterone, dehydroepiandrosterone sulfate (DHEA-S) and hs-CRP levels were measured.
Results: Mean age of patients was 23.5±8.7 years with the range of 15 to 49 years. In both groups significant decreases in DHEA-S levels and in Cyproterone-estradiol compound group a significant decrease in testosterone levels were seen after 6 months, but there were no significant decrease on hs- CRP levels. Comparison of two groups showed that there were no significant differences in the effects of these two drugs on serum testosterone, DHEA-S and hs-CRP levels. In our study the level of hs- CRP at the beginning of treatment were significantly higher in patients who were overweight and obese. Also we found that Cyproterone-estradiol compound causes significant decrease at the level of hs-CRP in overweight and obese patients.
Conclusion: The results of this study are different from those of previous studies about beneficial effects of Metformin on hs-CRP levels but are similar to the results of studies that revealed probably obesity and overweight has important role in inducing inflammation and increasing CRP levels.
KEY WORDS:
Poly Cystic Ovary Syndrome, Metformin, Cyproterone-estradiol compound, hs-CRP.Pak J Med Sci April - June 2010 Vol. 26 No. 2 347-351
How to cite this article:
Aghamohammadzadeh N, Aliasgarzadeh A, Baglar L, Abdollahifard S, Bahrami A, Najafipour F, et al. Comparison of Metformin and Cyproterone-estrodiol Compound effect on hs C-reactive protein and serum Androgen levels in patients with Poly Cystic Ovary Syndrome. Pak J Med Sci 2010;26(2): 347-351
1. Nasser Aghamohammadzadeh,
Assistant Professor of Endocrinology
2. Akbar Aliasgarzadeh,
Associate Professor of Endocrinology
3. Leila Baglar,
Obstetrician and Gynecologist
4. Seddigheh Abdollahifard,
Associate professor of Obstetric and Gynecology
5. Amir Bahrami,
Professor of Endocrinology
6. Farzad Najafipour,
Assistant Professor of Endocrinology
7. Mitra Niafar,
Assistant Professor of Endocrinology
1-7: School of Medicine,
Tabriz University (Medical Sceneries),
Emamreza Teaching Hospital –
Golgasht Avenue,
TABRIZ - IRAN.Correspondence:
Dr. Akbar Aliasgarzadeh
E – Mail: asgharzadeha@gmail.com
* Received for Publication: July 21, 2009
* 1st Revision Received: September 15, 2009
* 2nd Revision Received: March 2, 2010
* Final Revision Accepted: March 5, 2010
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