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Volume 25 |
April - June 2009 (Part-I) |
Number 2 |
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Published by : PROFESSIONAL MEDICAL PUBLICATIONS |
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Volume 25 |
April - June 2009 (Part-I) |
Number 2 |
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Double-blind, randomized, clinical trial of topiramate
versus sodium valproate for the treatment of
bipolar disorder in adolescents
Paria Hebrani1, Fatemeh Behdani2, Ali Akhoondpoor Manteghi3
ABSTRACT
Objective: To study the efficacy and safety of Topiramate versus Sodium Valproate for the Treatment of Bipolar Disorder in Adolescents
Methodology: One hundred twenty adolescents (aged 12-18) with an admission diagnosis of bipolar I disorder, manic or mixed episode were enrolled from the Adolescent Ward at Ebn-e-Sina Psychiatric Center of Mashhad University. They were assigned to receive 8 weeks of double-blinded, flexibly dosed treatment with topiramate or sodium valproate. The primary efficacy measure was the mean change from baseline to endpoint in the Young Mania Rating Scale (YMRS).
Results: Sodium Valproate was superior to topiramate. The YMRS scores decreased significantly in both groups. However, when efficacy of topiramte was analyzed, only 18.64% of the patients showed YMRS scores decrease more than 50% from baseline.
Conclusions: This study does not support the efficacy of topiramate as monotherapy in acute mania or mixed episodes in adolescents with bipolar I disorder and sodium valproate was found superior to topiramate.
KEY WORDS: Bipolar, Child and Adolescent, Topiramate, Sodium valproate.
Pak J Med Sci April - June 2009 Vol. 25 No. 2 247-252
How to cite this article:
Hebrani P, Behdani F, Manteghi AA. Double-blind, randomized, clinical trial of topiramate versus sodium valproate for the treatment of bipolar disorder in adolescents. Pak J Med Sci 2009;25(2):247-252.
1. Paria Hebrani,
Child & Adolescent Psychiatrist, Associate Professor,
2. Fatemeh Behdani,
Psychiatrist, Associate Professor,
3. Ali Akhoondpoor Manteghi,
Psychiatrist, Assistant Professor,
1-3: Department of Psychiatry,
Mashhad University of Medical Sciences,
Mashhad – Iran.
Correspondence
Paria Hebrani,
Horre Ameli Street,
Ebn-E- Sina Hospital,
Mashad,Iran.
Email: hebranip@mums.ac.ir
* Received for Publication: June 23, 2008
* Revision Received: July 11, 2008
* 2nd Revision Received: November 11, 2008
* Final Revision Accepted: January 25, 2009
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